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A Meta-synthetic Decision Support System in Virtual Prototyping for Complex Products

Chen Xi,Song Yubo,Wang Zhiquan,Wu Huizhong

Strategic Study of CAE 2006, Volume 8, Issue 2,   Pages 67-74

Abstract: virtual prototyping for complex products are difficult to use general decision-making methods and system engineeringBased on the analysis of the current DSS and the comparison between meta-synthetic decision support systemand current DSS, this paper proposed to establish meta-synthetic decision support system in virtualcomplex decision-making support problems effectively, analyzed the requirement of VPMSDSS from the meta-synthetic

Keywords： complex products     virtual prototyping     meta-synthetic decision support system     hall for workshop of meta-syntheticengineering     mobile agent     data mining    

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Advanced construction of science and technology with meta-synthetic wisdom

Dai Ruiwei

Strategic Study of CAE 2008, Volume 10, Issue 10,   Pages 4-8

Abstract:

The advanced construction of science and technology with meta-syntheticconstruction of science and technology, the research and discussion of intelligent system as well as meta-synthetic

Keywords： advanced construction of science and technology     meta-synthetic wisdom     open complex giant system (OCGS)     meta-synthesis     noetic science    

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A swarm intelligence design based on a workshop of meta-synthetic engineering Article

Bo-hu LI,Hui-yang QU,Ting-yu LIN,Bao-cun HOU,Xiang ZHAI,Guo-qiang SHI,Jun-hua ZHOU,Chao RUAN

Frontiers of Information Technology & Electronic Engineering 2017, Volume 18, Issue 1,   Pages 149-152 doi: 10.1631/FITEE.1700002

Abstract: In this paper, we present a swarm intelligence design technology based on a workshop of meta-syntheticengineering, including the architecture, the decision-making process of swarm intelligence design basedon a meta-synthetic workshop, and the design resource delivery technology involved in the design.

Keywords： Meta-synthetic engineering     Swarm intelligence     Design resources delivery    

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The Innovation in Theory and Policy-making Management Mechanism of Socialist Modernization Construction

Zhao Shaokui

Strategic Study of CAE 2002, Volume 4, Issue 8,   Pages 26-33

Abstract:

Based on the study of Qian Xuesen's latest work “Found the Theory on System”，this paper presents thoughts on how to accurately appraise the objective world, scientifically understand the objective world, vigorously greet the gauntlet of new century and carry forward socialist modernization construction with scientific theory.

Keywords： objective world     science and technology system     structure of socialist construction system     Meta-syntheticengineering     science decision     overall department    

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Genome reprogramming for synthetic biology

Kylie Standage-Beier,Xiao Wang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 37-45 doi: 10.1007/s11705-017-1618-2

Abstract: The ability to go from a digitized DNA sequence to a predictable biological function is central to syntheticGenome engineering tools facilitate rewriting and implementation of engineered DNA sequences.Recent development of new programmable tools to reengineer genomes has spurred myriad advances in syntheticAdvanced DNA synthesis and assembly methods have also enabled the construction of fully synthetic organismsHere we summarize the recent advances in programmable genome engineering tools.

Keywords： CRISPR     genome engineering     synthetic biology     rational design    

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Research on the Giant and Complex Financial Information System Engineering Management from the Perspectiveof Meta-synthesis Methodology—with the Bank Card Information Exchange System Engineering as a Sample

Hong-feng Chai,Quan Sun

Frontiers of Engineering Management 2016, Volume 3, Issue 4,   Pages 404-413 doi: 10.15302/J-FEM-2016037

Abstract: The paper empirically studies the engineering practices of the national currency circulation informationBy integrating the meta-synthesis methodology and the financial information system engineering, the paperproposes basic principles and processes of the giant and complex financial information system engineering

Keywords： financial information system     meta-synthesis methodology     bank card     information exchange    

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Qian Xuesen and Engineering Cybernetics

Zheng Yingping

Strategic Study of CAE 2001, Volume 3, Issue 10,   Pages 7-12

Abstract:

After a brief introduction to the contents, method and meanings of cybernetics and control engineeringwith a brief historical remark, Professor Qian Xuesen's《Engineering Cybernetics》is introduced withIn the preface he stated , “Engineering cybernetics is an engineering science, which aims to organizethe design principles used in engineering practice into a discipline and thus to exhibit the similaritiesbetween different areas of engineering practice and to emphasize the power of fundamental concepts&rdquo

Keywords： cybernetics     engineering cybernetics     engineering science     complex system control     complex giant system meta-synthesis    

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Designer enzyme for green materials innovation: Lactate-polymerizing enzyme as a key catalyst

Seiichi Taguchi

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 139-142 doi: 10.1007/s11705-017-1636-0

Abstract: typical topic of synthetic biology.

Keywords： synthetic biology     enzyme evolutionary engineering     polyhydroxyalkanoate    

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Efficacy and safety of benralizumab in patients with eosinophilic asthma: a meta-analysis of randomized

Ting Liu, Faping Wang, Geng Wang, Hui Mao

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 340-349 doi: 10.1007/s11684-017-0565-0

Abstract: We conducted a meta-analysis to evaluate the safety and efficacy of different doses of benralizumab inRandomized-effect models were used in the meta-analysis to calculate the pooled mean difference, relativeFurthermore, our meta-analysis showed that benralizumab with 30 mg (every eight weeks) dosage can improve

Keywords： benralizumab     anti-interleukin-5     monoclonal antibody     eosinophilic asthma     meta-analysis    

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Association between telomere length and survival in cancer patients: a meta-analysis and review of literature

Xinsen Xu,Kai Qu,Qing Pang,Zhixin Wang,Yanyan Zhou,Chang Liu

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 191-203 doi: 10.1007/s11684-016-0450-2

Abstract:

The relationship between telomere length and cancer survival has been widely studied. To gain a deeper insight, we reviewed the published studies. A total of 29 studies evaluated telomere length in the peripheral blood; 22 studies evaluated telomere length in the tumor tissue. First, in the peripheral blood studies, for solid tumor patients with shortened telomere length, the combined hazard ratios (HRs) for mortality and tumor progression were 1.21 (95%CI, 1.10–1.32) and 1.71 (95%CI, 1.37–2.13), respectively. Meanwhile, in hematology malignancy, the combined HRs for mortality and tumor progression were 2.83 (95%CI, 2.14–3.74) and 2.65 (95%CI, 2.18–3.22), respectively. Second, in the studies that use tumor tissue, for patients with shortened telomeres, the combined HRs for mortality and tumor progression were 1.26 (95%CI, 0.95–1.66) and 1.65 (95%CI, 1.26–2.15), respectively. In the studies that calculate the telomere length ratios of tumor tissue to adjacent normal mucosa, for patients with lower telomere length ratios, the combined HRs were 0.66 (95%CI, 0.53–0.83) and 0.74 (95%CI, 0.41–1.32) for mortality and tumor progression, respectively. In conclusion, shortened telomere in peripheral blood and tumor tissue might indicate poor survival for cancer patients. However, by calculating the telomere length ratios of tumor tissue to adjacent normal mucosa, the lower ratio might indicate better survival.

Keywords： telomere     survival     cancer     meta-analysis    

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Treatment outcomes of pulmonary tuberculosis in the past decade in the mainland of China: a meta-analysis

Xiangwei Li, Yu Yang, Jianmin Liu, Feng Zhou, Wei Cui, Ling Guan, Fei Shen, Cong Gao, Mufei Li, Qi Jin, Lei Gao

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 354-366 doi: 10.1007/s11684-013-0257-3

Abstract: treatment outcomes of smear-positive pulmonary TB in the mainland of China in the past decade using meta-analysis

Keywords： tuberculosis     treatment     outcome     China     meta-analysis    

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Engineering of

Ruizhao Wang,Xiaoli Gu,Mingdong Yao,Caihui Pan,Hong Liu,Wenhai Xiao,Ying Wang,Yingjin Yuan

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 89-99 doi: 10.1007/s11705-017-1628-0

Abstract: The conversion of -carotene to astaxanthin is a complex pathway network, in which two steps of hydroxylation and two steps of ketolation are catalyzed by -carotene hydroxylase (CrtZ) and -carotene ketolase (CrtW) respectively. Here, astaxanthin biosynthesis pathway was constructed in by introducing heterologous CrtZ and CrtW into an existing high -carotene producing strain. Both genes and were codon optimized and expressed under the control of constitutive promoters. Through combinatorial expression of CrtZ and CrtW from diverse species, nine strains in dark red were visually chosen from thirty combinations. In all the selected strains, strain SyBE_Sc118060 with CrtW from DC263 and CrtZ from sp. strain PC-1 achieved the highest astaxanthin yield of 3.1 mg/g DCW. Protein phylogenetic analysis shows that the shorter evolutionary distance of CrtW is, the higher astaxanthin titer is. Further, when the promoter of in strain SyBE_Sc118060 was replaced from FBA1p to TEF1p, the astaxanthin yield was increased by 30.4% (from 3.4 to 4.5 mg/g DCW). In the meanwhile, 33.5-fold increase on transcription level and 39.1-fold enhancement on the transcriptional ratio of to were observed at early exponential phase in medium with 4% (w/v) glucose. Otherwise, although the ratio of to were increased at mid-, late-exponential phases in medium with 2% (w/v) glucose, the transcription level of both and were actually decreased during the whole time course, consequently leading to no significant improvement on astaxanthin production. Finally, through high cell density fed-batch fermentation using a carbon source restriction strategy, the production of astaxanthin in a 5-L bioreactor reached to 81.0 mg/L, which was the highest astaxanthin titer reported in yeast. This study provides a reference to greatly enhance desired compounds accumulation by employing the key enzyme(s) in microbes.

Keywords： synthetic biology     astaxanthin     β-carotene hydroxylase     β-carotene ketolase     Saccharomyces    

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An update and cumulative meta-analysis

Jiangang Pan,Mo Liu,Xing Zhou

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 241-249 doi: 10.1007/s11684-014-0328-0

Abstract: recurrence in patients with NMIBC, we analyzed this relationship by conducting an updated detailed meta-analysis

Keywords： non-muscle invasive bladder cancer     bacillus Calmette-Guérin (BCG)     meta-analysis    

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Machine perfusion versus cold storage of livers: a meta-analysis

Sushun Liu,Qing Pang,Jingyao Zhang,Mimi Zhai,Sinan Liu,Chang Liu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 451-464 doi: 10.1007/s11684-016-0474-7

Abstract: preserved through machine perfusion (MP) or static cold storage (CS) were compared by conducting a meta-analysisTwenty-four studies involving MP preservation were included in the meta-analysis.

Keywords： machine perfusion     cold storage     DCD     meta-analysis    

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Chinese medicine combined with Western therapy on primary hepatic carcinoma: a systematic review with meta-analysis

Li Ma, Bin Wang, Yuanxiong Long, Hanmin Li

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 191-202 doi: 10.1007/s11684-017-0512-0

Abstract: This systematic review with meta-analysis aimed to assess the effect of TCM combined with Western therapyMeta-analysis results indicated that the overall effect of TCM and Western integrative treatment on PHC

Keywords： traditional Chinese medicine     primary hepatic carcinoma     meta-analysis    

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Title Author Date Type Operation

A Meta-synthetic Decision Support System in Virtual Prototyping for Complex Products

Chen Xi,Song Yubo,Wang Zhiquan,Wu Huizhong

Journal Article

Advanced construction of science and technology with meta-synthetic wisdom

Dai Ruiwei

Journal Article

A swarm intelligence design based on a workshop of meta-synthetic engineering

Bo-hu LI,Hui-yang QU,Ting-yu LIN,Bao-cun HOU,Xiang ZHAI,Guo-qiang SHI,Jun-hua ZHOU,Chao RUAN

Journal Article

The Innovation in Theory and Policy-making Management Mechanism of Socialist Modernization Construction

Zhao Shaokui

Journal Article

Genome reprogramming for synthetic biology

Kylie Standage-Beier,Xiao Wang

Journal Article

Research on the Giant and Complex Financial Information System Engineering Management from the Perspectiveof Meta-synthesis Methodology—with the Bank Card Information Exchange System Engineering as a Sample

Hong-feng Chai,Quan Sun

Journal Article

Qian Xuesen and Engineering Cybernetics

Zheng Yingping

Journal Article

Designer enzyme for green materials innovation: Lactate-polymerizing enzyme as a key catalyst

Seiichi Taguchi

Journal Article

Efficacy and safety of benralizumab in patients with eosinophilic asthma: a meta-analysis of randomized

Ting Liu, Faping Wang, Geng Wang, Hui Mao

Journal Article

Association between telomere length and survival in cancer patients: a meta-analysis and review of literature

Xinsen Xu,Kai Qu,Qing Pang,Zhixin Wang,Yanyan Zhou,Chang Liu

Journal Article

Treatment outcomes of pulmonary tuberculosis in the past decade in the mainland of China: a meta-analysis

Xiangwei Li, Yu Yang, Jianmin Liu, Feng Zhou, Wei Cui, Ling Guan, Fei Shen, Cong Gao, Mufei Li, Qi Jin, Lei Gao

Journal Article

Engineering of

Ruizhao Wang,Xiaoli Gu,Mingdong Yao,Caihui Pan,Hong Liu,Wenhai Xiao,Ying Wang,Yingjin Yuan

Journal Article

An update and cumulative meta-analysis

Jiangang Pan,Mo Liu,Xing Zhou

Journal Article

Machine perfusion versus cold storage of livers: a meta-analysis

Sushun Liu,Qing Pang,Jingyao Zhang,Mimi Zhai,Sinan Liu,Chang Liu

Journal Article

Chinese medicine combined with Western therapy on primary hepatic carcinoma: a systematic review with meta-analysis

Li Ma, Bin Wang, Yuanxiong Long, Hanmin Li

Journal Article